SPIN LABEL TECHNIQUES FOR DETECTION OF MALIGNANT HYPERTHERMIA
نویسندگان
چکیده
منابع مشابه
Detection of malignant hyperthermia susceptibility using a spin label technique on red blood cells.
Using spin labelled red blood cells and electron paramagnetic resonance spectroscopy (EPR), we observed that halothane 3 mmol litre-1 produced a much greater decrease in the rotational correlation time of red blood cells from individuals who were at risk for malignant hyperthermia (MH), compared with normals. Subsequently we performed blind tests on 14 individuals whose MH susceptibility status...
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''Malignant Hypothermia'' syndrome is a rare, but dangerous occurrence, the aetiology of which is not known. Up to this date 180 cases have been reported. This syndrome i's seen generally in :male children over age of two years, and especially in adolescent males. Also those people with muscular abnormalities are more susciptable to this illnes'S. Anaesthetic agent such as halothane or muscular...
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Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disease triggered by several anaesthetic agents. The in vitro muscle contracture test (IVCT) is the standard test to establish an individual's risk of susceptibility to MH. Clinical practitioners and geneticists of the European MH Group have agreed on the present guidelines for the detection of MH susceptibility using molecular ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1993
ISSN: 0007-0912
DOI: 10.1093/bja/71.6.921-b